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In healthy individuals, Cytomegalovirus (CMV) infections are controlled by CMV-specific cell-mediated immunity (CMI). However, functional impairment of the CMI in immunocompromized individuals can lead to uncontrolled CMV-replication. Thus, monitoring CMV-specific CMI is highly relevant for the prognosis of CMV-associated diseases. Here we show the optimization and technical validation of a monitoring tool for the determination of CMV-specific CMI.
Background Cytomegalovirus (CMV) is the most common congenital viral infection. Mother-to child transmission (MTCT) can cause severe disability of the child. Intact CMV-specific cell-mediated immunity (CMI) has been shown to prevent uncontrolled replication in healthy individuals. In this study we aim to determine whether CMV-specific CMI is impaired in pregnant women, thus increasing the overall risk for active CMV replication and transmission.
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