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Sascha Barabas on Muck Rack

Sascha Barabas

As seen in: MDPI, The Journal of Immunology
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Articles

Monitoring the Cytomegalovirus-specific cellular immunity in lung transplant recipients: A comparative analysis of two assay systems

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By Katharina Boeckl, Sascha Barabas, Hannah Striebinger, Nikolaus Kneidinger, Claus Neurohr
| The Journal of Immunology Verified
Objective Monitoring the cellular immunity for Cytomegalovirus (CMV) in organ transplant recipients is a promising tool to support prevention strategies for posttransplant CMV infection or reactivation. Commercially available in vitro test systems differ substantially in their capacity to stimulate subpopulations of T-lymphocytes. We compared two assays for CMV immune monitoring in respect of their clinical practicability and significance.
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An optimized IFN-γ ELISpot assay using

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By Katharina Boeckl, Nina Körber, Sascha Barabas, Ludwig Deml, Tanja Bauer
| The Journal of Immunology Verified
In healthy individuals, Cytomegalovirus (CMV) infections are controlled by CMV-specific cell-mediated immunity (CMI). However, functional impairment of the CMI in immunocompromized individuals can lead to uncontrolled CMV-replication. Thus, monitoring CMV-specific CMI is highly relevant for the prognosis of CMV-associated diseases. Here we show the optimization and technical validation of a monitoring tool for the determination of CMV-specific CMI.
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Functional impairment of CMV-reactive cellular immunity during pregnancy

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By Katharina Boeckl, Sascha Barabas, Ludwig Deml, Edith Reuschel, Hanna Bendfeldt
| The Journal of Immunology Verified
Background Cytomegalovirus (CMV) is the most common congenital viral infection. Mother-to child transmission (MTCT) can cause severe disability of the child. Intact CMV-specific cell-mediated immunity (CMI) has been shown to prevent uncontrolled replication in healthy individuals. In this study we aim to determine whether CMV-specific CMI is impaired in pregnant women, thus increasing the overall risk for active CMV replication and transmission.
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