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Luis Andre Baptista on Muck Rack

Luis Andre Baptista

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Sequence-encoded hexagonal lattices in multichannel peptide nanofibrils

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By Francesca Mazzotta, Nikolay Stoyanov, Matthias Schmidt Verified, Nico Alleva, Thunchanok Thummaraj, Cong Zhou, Lei Gao, Jan Münch, Mischa Bonn, Marcus Fändrich, Ingo Lieberwirth, Robinson Cortes-Huerto, Katharina Landfester, Tanja Weil, Luis Andre Baptista, Fanny Bonnicel
| Nature Verified
Abstract Structural complexity in biological matter arises from molecular information that encodes supramolecular assembly across length scales1,2,3. Here we show that minimal nine-residue peptides can encode discrete lateral interaction motifs that direct supramolecular organization. These motifs generate hexagonal pores and hierarchically tile into multichannel nanofibrils with defined topology.
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