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Abstract Hypoxia is a significant source of metabolic stress that activates many cellular pathways involved in cellular differentiation, proliferation, and cell death. Hypoxia is also a major component in many human diseases, and a known driver of many cancers.
New Results doi: https://doi.org/10.1101/2023.03.14.532258 Abstract Enhancer reprogramming has been proposed as a key source of transcriptional dysregulation during tumorigenesis, but the molecular mechanisms underlying this process remain unclear. Here, we identify an enhancer cluster required for normal development that is aberrantly activated in breast and lung carcinoma.
New Results doi: https://doi.org/10.1101/2023.03.14.532258 Abstract Enhancer reprogramming has been proposed as a major source of gene expression dysregulation during tumorigenesis. Here, we identify SOX2 developmental enhancers that are misactivated in breast and lung carcinoma. Deletion of the SRR124-134 enhancer cluster disrupts SOX2 transcription and genome-wide chromatin accessibility in cancer cells.
Loading metrics Open Access Peer-reviewed Research Article Virlana M. Shchuka , Luis E. Abatti , Huayun Hou, Nawrah Khader, Anna Dorogin, Michael D. Wilson, Oksana Shynlova , Jennifer A. Mitchell Virlana M. Shchuka, Luis E. Abatti, Huayun Hou, Nawrah Khader, Anna Dorogin, Michael D. Wilson, Oksana Shynlova, Jennifer A.
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