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RNA neoantigen vaccines prime long-lived CD8 + T cells in pancreatic cancer

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By Zachary Sethna, Pablo Guasp, Charlotte Reiche, Martina Milighetti, Nicholas Ceglia, Erin Patterson, Jayon Lihm, George Payne, Olga Lyudovyk, Luis Rojas, Nan Pang, Akihiro Ohmoto, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, Emmanuel Bruno, Siqi Zhang, Charlotte Cheng, Yuval Elhanati, Evelyna Derhovanessian, Luisa Manning, Ina Rhee, Mahesh Yadav, Taha Merghoub, Jedd D. Wolchok, Olca Basturk, Mithat Gonen, Andrew Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna Varghese, Avni Desai, Alice C Wei, Michael I. D’Angelica, T. Peter Kingham, Kevin C. Soares, William R. Jarnagin, Jeffrey Drebin, Eileen M. O’Reilly, Ira Mellman, Ugur Sahin, Ozlem Tureci, Benjamin D. Greenbaum, Vinod P. Balachandran, Felicitas Müller, Elizabeth Won
| Nature Verified
Abstract A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA–lipoplex vaccines against somatic mutation-derived neoantigens may solve this challenge in pancreatic ductal adenocarcinoma (PDAC), a lethal cancer with few mutations.
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