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Luise-Elektra Keller on Muck Rack

Luise-Elektra Keller

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Articles

The periphery of nuclear speckles defines a spatially and temporally regulated compartment of long-lived intron-retained RNAs that resolves during mitosis

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By Josep Biayna, Artem Baranovskii, Anusha Chaudhuri, A. Rasim Barutcu, Stefanie Dimmeler, Annalisa Marsico, Gabrijela Dumbović, Marta Paladin, Berkay Erdem, Luise-Elektra Keller
| Nature Verified
Abstract RNA localization adds a fundamental layer to gene expression by determining when and where translation-ready mRNAs become available, yet how this timing is coordinated with nuclear architecture and cell-cycle progression remains unclear. Here we identify a subnuclear RNA niche at the nuclear speckle periphery that couples intron retention to cell-cycle-timed RNA release.
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