Luiz F. Barella

Abstract Pancreatic islets undergo coordinated cellular remodeling during obesity-induced insulin resistance (IR). However, the associated molecular changes across endocrine and non-endocrine compartments remain largely unexplored.

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-49537-x, published online 15 June 2024 The original version of this Article omitted from the author list the 6th author Sarah M. Gray, who is from the ‘Duke Molecular Physiology Institute’.

Abstract Glucagon, a hormone released from pancreatic α-cells, is critical for maintaining euglycemia and plays a key role in the pathophysiology of diabetes. To stimulate the development of new classes of therapeutic agents targeting glucagon release, key α-cell signaling pathways that regulate glucagon secretion need to be identified. Here, we focused on the potential importance of α-cell Gs signaling on modulating α-cell function.