Lukasz Jan Bugaj

Abstract Protein clustering is a powerful form of optogenetic control, yet there is currently only one protein, Cry2, whose light-induced clustering has been harnessed for these purposes. Recently, the photoreceptor BcLOV4 was found to form protein clusters in mammalian cells in response to blue light, although clustering coincided with its translocation to the plasma membrane, potentially constraining its application as an optogenetic clustering module.