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Lukasz Majewski on Muck Rack

Lukasz Majewski

As seen in: BioRxiv, Emulsive

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Lukasz Majewski’s Biography

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http://www.stworz-siebie-na-nowo.pw/ - Dzień dobry, ściskam wszystkich zafascynowanych sprawami modowymi. Mam na imię Kasia, od zawsze moją nieszkodliwą obsesją jest moda i wszystko co jej dotyczy, od kosmetyków, poprzez stylizacje, aż po modne dodatki. Na moim blogu natrafisz na zaskakujące wpisy oraz znajdziesz pomocne rady, które pokażą jak stworzyć fajniejszą wersję siebie samej. Zapraszam.

Articles

Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish

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By Iga Wasilewska, Dobrochna Adamek-Urbańska, Sofiia Baranykova, Lukasz Majewski
| BioRxiv
Abstract Mitochondrial calcium homeostasis involves coordinated uptake via the mitochondrial calcium uniporter (MCU) and efflux through sodium-dependent NCLX (encoded by SLC8B1). Mild Mcu knockout phenotypes suggest additional transport mechanisms. We investigated TMBIM5, a proposed bidirectional mitochondrial calcium/proton transporter, by generating zebrafish lacking tmbim5, slc8b1, plus tmbim5/mcu and tmbim5/slc8b1 double knockouts.
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Tmbim5 loss causes muscle atrophy without exacerbating mcu or slc8b1 knockout phenotypes

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By Iga Wasilewska, Dobrochna Adamek-Urbańska, Sofiia Baranykova, Lukasz Majewski
| BioRxiv
Abstract Mitochondria generate ATP by establishing a proton gradient across the inner membrane, which also drives calcium uptake via the mitochondrial calcium uniporter (MCU), while sodium-dependent NCLX (encoded by SLC8B1) facilitates efflux. The absence of severe phenotypes in MCU-knockout models suggests redundant calcium transport mechanisms. We investigated the role of TMBIM5, a potential bidirectional mitochondrial calcium transporter, by generating zebrafish lacking Tmbim5, Slc8b1, or both.
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Tmbim5 loss causes muscle atrophy in zebrafish without exacerbating mcu or slc8b1 knockout phenotypes

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By Dobrochna Adamek-Urbańska, Lukasz Majewski, Iga Wasilewska, Sofiia Baranykova
| BioRxiv
Abstract Mitochondria generate ATP by creating a proton gradient across the inner membrane. This gradient also drives calcium uptake by the mitochondrial calcium uniporter (MCU) complex, while NCLX, encoded by SLC8B1, facilitates efflux. Mcu deficiency in various species does not result in obvious phenotypes, suggesting the existence of additional calcium transport systems.
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Awards

Investigative Reporters and Editors Award

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