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Keywords immunothrombosis thrombosis immune landscape neutrophils monocytes innate immunity single-cell multi-omics immunothrombolysis thrombus resolution immunothrombotic dysregulation thromboinflammation stroke immune-cell plasticity organ ischemia Introduction Thrombosis and thromboembolism are a major global cause of morbidity and mortality by leading to myocardial infarction, stroke, and venous thromboembolism.1,2 Simultaneously, anti-thrombotic therapies carry a relevant risk of...
Research Article HEALTH AND MEDICINE Rainer Kaiser https://orcid.org/0000-0003-1750-3395 rainer.kaiser@med.uni-muenchen.de, Christoph Gold https://orcid.org/0009-0008-8994-1021, [...] , Markus Joppich https://orcid.org/0000-0002-6665-8951, Quentin Loew, [...] , Anastassia Akhalkatsi, Tonina T.
Highlights • Mural cell-derived macrophage chemoattractants preserve the vascular macrophage niche • Interference with this axis results in repositioning and reduced macrophage coverage • This is accompanied by detrimental shifts in macrophage phenotype and function • Disruption of mural cell-macrophage communication exacerbates inflammation Summary Maladaptive, non-resolving inflammation contributes to chronic inflammatory diseases such as atherosclerosis.
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