Luladey Ayalew on Muck Rack

Luladey Ayalew

As seen in: ACS Publications
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Articles

Analytical Assessment of sgRNA Impurities and Their Impact on Functional Performance Click to copy article link Article link copied!

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By Kamalakar Chatla, Luladey Ayalew, Mandy Yim
| dx.doi.org
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Analytical Assessment of sgRNA Impurities and Their Impact on Functional Performance Click to copy article link Article link copied!

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By Kamalakar Chatla, Luladey Ayalew, Mandy Yim
| ACS Publications
Abstract Click to copy section linkSection link copied! Single guide RNA (sgRNA) is a critical component of the clustered, regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome-editing system, guiding Cas9 to specific genomic loci for precise DNA modification.
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Assessing mRNA and sgRNA Quality for Cell and Gene Therapy Applications Using Nanopore Direct RNA Sequencing

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By Kamalakar Chatla, Brian Roper, Luladey Ayalew
| ACS Publications
Abstract Click to copy section linkSection link copied! Recent advances in RNA technology have enabled the development of diverse therapeutics spanning vaccines, immunotherapies, and genome-editing platforms. Ensuring clinical efficacy and safety requires precise characterization and control of RNA critical quality attributes (CQAs).
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