Lunhua Huang on Muck Rack

Lunhua Huang

As seen in: Cell Reports Medicine
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Articles

Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity

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By Rou Zhao, Baoyu He, Yanli Wu, Ting Liu, Jilan Liu, Mingsheng Zhao, Tao Zhong, Yanhua Zhang, Xiao Zhang, Huabao Xiong, Bin Zhang, Qingli Bie, Lunhua Huang
| Cell Reports Medicine Verified
Keywords cancer stem cell AQP5 NK cell urea cycle TCA cycle Introduction Cancer stem cells (CSCs) with long-term tumorigenic capacity play a pivotal role in tumor progression, recurrence, metastasis, and drug resistance, making them important therapeutic targets.1 Like normal stem cells, CSCs also require a stem cell niche, which exhibits characteristics typical of the tumor microenvironment (TME), to promote cancer progression.2 The TME is composed of diverse cell populations and the...
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