Luoxing Xia

Abstract Accurate detection of microhepatocellular carcinoma (HCC) remains a major clinical challenge owing to the limited specificity and sensitivity of current imaging modalities. Herein, we present a dual-injection magnetic resonance imaging (MRI) peptidic probe based on in vivo membrane engineering, achieving in situ signal amplification and molecularly precise imaging.

Originally published19 Nov 2020https://doi.org/10.1161/CIRCULATIONAHA.120.049715Circulation. ;0 Abstract Background: Aberrant expression of circular RNA (CircRNA) contributes to human diseases. CircRNAs regulate gene expression by sequestering specific microRNAs (miRNAs). In this study, we investigated whether CircMAP3K5 could act as a competing endogenous miR-22-3p sponge and regulate neointimal hyperplasia.