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Luozixian Wang

As seen in: BioRxiv
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Articles

Spatial transcriptomic profiling of human retinoblastoma

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By Sandy Shen-Chi Hung, Luozixian Wang, Daniel Urrutia-Cabrera, Roy C.K. Kong
| BioRxiv
Abstract Retinoblastoma (RB) represents one of the most prevalent intraocular cancers in children. Understanding the tumor heterogeneity in RB is important to design better targeted therapies. Here we used spatial transcriptomic to profile human retina and RB tumor to comprehensively dissect the spatial cell-cell communication networks. We found high intratumoral heterogeneity in RB, consisting of 10 transcriptionally distinct subpopulations with varying levels of proliferation capacity.
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