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Articles

Nintedanib inhibits the VEGFR–ERK signaling pathway in human KRAS -mutated cancer cells

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By Sivasundaram Karnan, Akinobu Ota, Muhammad Hasan, Toshinori Hyodo, Nushrat Jahan, Hideki Murakami, Ichiro Hanamura, Lâm Vũ, Miho Riku, Hideaki Ito, Yoshifumi Kaneko, Yinzhi Lin, LUTFUR RAHMAN, Shingo Inaguma, Takuya Matsui, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa
| Nature Verified
Abstract KRAS mutations are significant drivers in various cancers, and existing drug discovery attempts targeting these mutations have largely been unsuccessful, emphasizing the need for more effective therapies. In this study, the screening library, which contains 1,374 chemical compounds, identified nintedanib, a VEGFR inhibitor, as exerting a potent and selective antiproliferative effect against KRAS-mutant cells, surpassing other VEGFR inhibitors.
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Ecofriendly synthesis and characterization of copper chitosan nanoparticles (CuChNPs) and assessing combined effect of nanoparticles and bismerthiozol against bacterial leaf blight of rice

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By Rumana Akter, LUTFUR RAHMAN, Omar Kayess, Rakibul Hasan, Mohammad Abdul Latif, A. K. M. Sahfiqul Islam
| Nature Verified
Abstract The rice bacterial blight pathogen, Xanthomonas oryzae pv. oryzae (Xoo), poses a major threat to global rice production. While chitosan and copper-based nanoparticles have been explored for plant disease control, their potential to function as synergistic boosters for reducing conventional agrochemical dosage remains largely underexploited.
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A Comprehensive Revisit to the Safe-Haven Assets Literature

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By Javed Bin Kamal, LUTFUR RAHMAN
| Wiley Online Library Verified
1 Introduction Safe-haven assets have received significant attention in recent literature due to the recurrence of financial crises and the high volatility of stock markets. Liquidity premium, term premium, and default risk premium are usually the most important factors that investors look for when they invest1 in risky long-term assets. Stock markets are the most important vehicle of investment for investors, with a global market value of approximately USD 127 trillion in 20242.
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