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Luzia Gyr on Muck Rack

Luzia Gyr

As seen in: Nature
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Articles

The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis - Nature Communications

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By Andreas Römpp, Paul J. Converse, Luzia Gyr, Eric Nuermberger, Dominik Schwudke, Michael Hoelscher, Christoph Hölscher, Julia Dreisbach, Leon Gröschel
| Nature Verified
Abstract The development of granulomas with central necrosis harboring Mycobacterium tuberculosis (Mtb) is the hallmark of human tuberculosis (TB). New anti-TB therapies need to effectively penetrate the cellular and necrotic compartments of these lesions and reach sufficient concentrations to eliminate Mtb. BTZ-043 is a novel antibiotic showing good bactericidal activity in humans in a phase IIa trial.
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Solution Phase and Surface Photoisomerization of a Hydrazone Switch with a Long Thermal Half-Life

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By Li-Qing Zheng, Sirun Yang, Jinggang Lan, Luzia Gyr
| American Chemical Society
Photoswitches can be employed for various purposes, with the half-life being a crucial parameter to optimize for the desired application. The switching of a photochromic hydrazone functionalized with a C6 alkyl thiolate spacer (C6 HAT) was characterized on a number of metal surfaces. C6 HAT exhibits a half-life of 789 years in solution. Tip-enhanced Raman spectroscopy (TERS) was used to study the photoisomerization of the C6 HAT self-assembled monolayers (SAMs) on Au, Ag, and Cu surfaces.
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Characterization of a Nitrogen-Based Dielectric Barrier Discharge Ionization Source for Mass Spectrometry Reveals Factors Important for Soft Ionization

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By Renato Zenobi, Luzia Gyr, Felix D. Klute, Joachim Franzke
| American Chemical Society
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