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Frontiers | Multi-omics machine learning identifies diagnostic gene signatures and functionally supports PRKACB involvement in macrophage inflammatory responses in sepsis
Introduction Sepsis is a life-threatening syndrome caused by an excessive and dysregulated immune response to infection, leading to systemic inflammation, organ failure, and high mortality (1, 2). Despite therapeutic advances, sepsis still affects over 30 million people annually, with mortality exceeding 25-50% (3, 4).
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