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Lyrialle W. Han on Muck Rack

Lyrialle W. Han

As seen in: Drug Metabolism and Disposition (ASPET)
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Articles

Efflux transporters in drug disposition during pregnancy

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By Xin Chen, Lyrialle W. Han, Sibylle Heidelberger, Chunying Gao
| Drug Metabolism and Disposition (ASPET)
Abstract Evidence-based dose selection of drugs in pregnant women has been lacking due to challenges in studying maternal-fetal pharmacokinetics. Hence, many drugs are administered off-label during pregnancy based on data obtained from non-pregnant women. During pregnancy, drug transporters play an important role in drug disposition along with known gestational age-dependent changes in physiology and drug-metabolizing enzymes.
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Key hepatic metabolic pathways are altered in germ-free mice during pregnancy

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By Yuanyuan Shi, Alison G. Paquette, Lu Wang Verified, Lyrialle W. Han
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Lyrialle W. Han, Yuanyuan Shi, Alison Paquette, Lu Wang, Theo K. Bammler, Qingcheng Mao Lyrialle W. Han, Yuanyuan Shi, Alison Paquette, Lu Wang, Theo K. Bammler, Qingcheng Mao Published: March 12, 2021 https://doi.org/10.1371/journal.pone.0248351 Figures Abstract Pregnancy is associated with metabolic changes to accommodate the mother and her growing fetus.
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