M. H. Barros

By P. Joshi, M. Barros, S. Tindal, M. Leuthold The concepts of intensified and continuous bioprocessing are central to current discussions in biomanufacturing, offering the potential for more efficient and cost-effective production across upstream and downstream processes. Continuous tangential flow filtration (TFF) and diafiltration are critical technologies for downstream processing. This study introduces an innovative flat sheet membrane device designed for TFF diafiltration.

1 Introduction The boar taint is an unpleasant odour found in the meat of 5 to 10 % of uncastrated male pigs1-4 (Aluwe et al., 2020; Baek et al., 1997; EFSA, 2004; Fredriksen et al., 2011) mainly caused by the accumulation of androstenone and skatole5. As animals mature during puberty, these compounds build up in their adipose tissue6, leading to the development of off-odours and off-flavours, creating an unfavourable perception of pork quality among consumers.

Abstract The microenvironment in classical Hodgkin lymphoma (cHL) comprises a mixture of different types of cells, which are responsible for lymphoma pathogenesis and progression. Even though microenvironment composition in adult cHL has been largely studied, only few groups studied pediatric cHL, in which both Epstein Barr virus (EBV) infection and age may display a role in their pathogenesis.