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Articles by M. Le
Auto contro trattore, muore un 35enne
Alla guida del suo trattorino stava rientrando a casa a Samassi dall’appezzamento di terreno dove coltivava frutta e ortaggi, quando all’improvviso è stato urtato da una Audi Q5. Il piccolo mezzo agricolo è uscito di strada e si è ribaltato, travolgendolo senza lasciargli scampo: Daniele Cabras, 35 anni, è morto sul colpo. Inutili i tentativi di salvargli la vita da parte dei medici del 118, sopraggiunti sul posto a bordo di un’ambulanza. Illeso invece il conducente dell’auto.
Methylation Mesa define functional regulatory elements for targeted gene activation
Abstract DNA methylation regulates transcription, yet the demethylation of canonical elements like promoter CpG islands exhibits inconsistent correlations with gene activation. We hypothesize that causal regulatory elements are defined by biophysical hypersensitivity. Profiling 24 whole-genome bisulfite sequencing samples across diverse human and murine models, we identify Methylation Mesa, narrow (~45-300 bp), structurally conserved epigenetic regulatory elements.
Mid-infrared quantum cascade laser-based structured illumination microscope
We demonstrate, for the first time to the best of our knowledge, the implementation of Spatial Frequency Modulated Imaging (SPIFI) microscopy in the mid-infrared region using a Quantum Cascade Laser (QCL) source. Hyperspectral imaging in the mid-infrared (3–20 μm) enables chemically specific mapping and structural imaging based on molecular contrast, which is otherwise inaccessible in the visible or near-infrared region.
Astrophysics > Cosmology and Nongalactic Astrophysics
[Submitted on 4 Sep 2025 (v1), last revised 30 Oct 2026 (this version, v2)] View PDF HTML (experimental) Comments: Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO) Cite as: arXiv:2509.04073 [astro-ph.CO] (or arXiv:2509.04073v2 [astro-ph.CO] for this version) https://doi.org/10.48550/arXiv.2509.04073
Evaluation of potential changes in prescribing patterns through the use of an HIV interactions checker database
26 Background: People ageing with HIV often experience comorbidities and polypharmacy, leading to a higher risk for adverse events and drug–drug interactions (DDIs). On the other hand, contemporary antiretrovirals have a lower potential for DDIs which may, in turn, have an impact on the treatment of common comorbidities (e.g., cardiovascular, mental diseases and opportunistic infections).
Magnetic properties of a staggered $S=1$ chain with an alternating single-ion anisotropy direction
Materials composed of spin-1 antiferromagnetic (AFM) chains are known to adopt complex ground states that are sensitive to the single-ion-anisotropy (SIA) energy (), and intrachain () and interchain () exchange energy scales. While theoretical and experimental studies have extended this model to include various other energy scales, the effect of the lack of a common SIA axis is not well explored.
Kitaev interactions through extended superexchange pathways in the $${j}_{{\mathsf{eff}}}=1/2$$ j eff = 1 / 2 Ru3+ honeycomb magnet RuP3SiO11 - Nature Communications
Abstract Magnetic materials are composed of the simple building blocks of magnetic moments on a crystal lattice that interact via magnetic exchange. Yet from this simplicity emerges a remarkable diversity of magnetic states. Some reveal the deep quantum mechanical origins of magnetism, for example, quantum spin liquid (QSL) states in which magnetic moments remain disordered at low temperatures despite being strongly correlated through quantum entanglement.
Risking everything to save lives
The fire prevention and rescue service is one of the most dangerous and hazardous professions. Officers in this field constantly face life-threatening situations while carrying out their duties, be it firefighting or rescuing those in peril. From building collapses to near-death experiences, these brave men and women remain steadfast, always putting the lives and property of citizens above all else.
Guided Mode Evolution and Ionization Injection in Meter-Scale Multi-GeV Laser Wakefield Accelerators
Abstract We show that multi-GeV laser wakefield electron accelerators in meter-scale, low density hydrodynamic plasma waveguides operate in a new nonlinear propagation regime dominated by sustained beating of lowest order modes of the ponderomotively modified channel; this occurs whether or not the injected pulse is linearly matched to the guide.
Loss-free shaping of few-cycle terawatt laser pulses
We demonstrate loss-free generation of 3 mJ, 1 kHz, few-cycle (5 fs at 750 nm central wavelength) double pulses with a pulse peak separation from 10 to 100 fs, using a helium-filled hollow core fiber (HCF) and chirped mirror compressor. Crucial to our scheme are simulation-based modifications to the spectral phase and amplitude of the oscillator seed pulse to eliminate the deleterious effects of self-focusing and nonlinear phase pickup in the chirped pulse amplifier.
In Situ Calibration of Wetlabs Chlorophyll Sensors: A Methodology Adapted to Profile Measurements
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Joëlle Salaün * and Marc Le Menn Shom, French Navy Hydrographic and Oceanographic Service, 29228 Brest, France * Author to whom correspondence should be addressed.
Abstract No. 325 Assessment of central line infections based on patient location: retrospective chart review
With a national central line associated bloodstream infection (CLABSI) rate in the intensive care unit (ICU) of 0.8 per 1000 line days,1 there is concern regarding the risks of placement of tunneled central venous catheters (CVCs) in acutely ill patients. This study aims to compare the risk of developing an infection after placement of a tunneled CVC in adult patients in the ICU versus non-ICU inpatient settings.
Abstract No. 605 An algorithm to flag totally implantable venous access port infections for the administration of chemotherapy using unstructured and structured data in the Veterans Health Administration’s electronic medical record
Abstract No. 602 Transjugular intrahepatic portosystemic shunt (TIPS) creation: are high splenic volumes a reliable predictor of high portal venous pressures and thrombocytopenia during TIPS creation?
Abstract No. 601 MELD-Na, albumin, and age as novel predictors of 1-year mortality in cirrhotic patients undergoing elective TIPS
Abstract No. 613 Outcomes of IVC filters placed for controversial indications
Indications for IVC filter placement vary by different societal guidelines (1-4). Controversial indications include low-volume venous thromboembolism (VTE) and prophylaxis in high-risk patients. The goal of the study is to examine the outcomes of filters placed for these indications.
M079 A CASE OF CHRONIC LYMPHOCYTIC LEUKEMIA UNVEILED IN A PATIENT PRESENTING WITH EOSINOPHILIA
Complete blood count (CBC) with differential is often used by allergists to determine absolute eosinophil count (AEC), which may help phenotype asthma. Although tempting to focus on one’s area of expertise, the practitioner ordering a diagnostic test is responsible for addressing all abnormalities. We present a case of chronic lymphocytic leukemia (CLL) uncovered by CBC obtained to phenotype asthma.
099 Comparison of the use of Sacubitril/Valsartan and Mineralocorticoid Receptor Antagonists in Acute Decompensated Heart Failure With Reduced Ejection Fraction (HFrEF) in a Tertiary Hospital
M. Le A. Hussein A. Prosser M. Horsfall K. Lambrakis T. Hecker R. Lek J. Harris J. Harris Affiliations Department of Cardiology, Flinders Medical Centre, Adelaide, AustraliaCollege of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia Search for articles by this author C. Burdeniuk C.
Libration-driven flows in ellipsoidal shells
Planets and satellites can undergo physical librations, which consist of forced periodic variations in their rotation rate induced by gravitational interactions with nearby bodies. This mechanical forcing may drive turbulence in interior fluid layers such as subsurface oceans and metallic liquid cores through a libration-driven elliptical instability (LDEI) that refers to the resonance of two inertial modes with the libration-induced base flow.
Neandertal cannibalism and Neandertal bones used as tools in Northern Europe
The reanalysis of the Goyet material comprised (i) the revision of the human skeletal material, (ii) systematic sorting of the faunal collections to check for unidentified human remains (Supplementary Fig. S2), and (iii) a multidisciplinary study of the human remains and their context.
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