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Boron trifluoride (BF3) is a kind of important chemical substance, which is commonly used as a catalyst for organic reactions, for instance, etherification, condensation, cationic polymerization, N-benzylation, alkylation and isomerization [[1], [2], [3], [4], [5], [6]]. Because of its electron-absorbing property, BF3 is often used as Lewis acid catalyst in the manufacture of semiconductors and battery electrolyte [[7], [8], [9], [10]].
Introduction: Around 10%–30% of classical Hodgkin's lymphoma(cHL) will relapse or refract after treatment with traditional cytotoxic drug-based chemotherapy, meanwhile the chemotherapy-related toxicity cannot be ignored. In order to balance efficacy and toxicity, we use the concept of ‘Smart Start’ to explore the efficacy and safety of tislelizumab sequentially combined with AVD regimen in the first-line treatment of cHL in phase II study (NCT04843267).
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