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Ma Luisa Gaspar on Muck Rack

Ma Luisa Gaspar

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Articles

Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice - Nature Communications

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By Marta Isidro-Hernández, Ninad Oak, Jorge Martínez-Cano, Alberto Órfão, África Gonzalez-Murillo, Carolina Vicente-Dueñas, Cesar Cobaleda, Kim Nichols, Silvia Alemán-Arteaga, Ma Luisa Gaspar, Diego Alonso-López, Susana Riesco, Pablo Prieto-Matos, Manuel Ramírez-Orellana, Belén de Andrés
| Nature Verified
Abstract The initial steps of B-cell acute lymphoblastic leukemia (B-ALL) development usually pass unnoticed in children. Several preclinical studies have shown that exposure to immune stressors triggers the transformation of preleukemic B cells to full-blown B-ALL, but how this takes place is still a longstanding and unsolved challenge. Here we show that dysregulation of innate immunity plays a driving role in the clonal evolution of pre-malignant Pax5+/− B-cell precursors toward leukemia.
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