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Maa O. Quartey

As seen in: Cell Chemical Biology
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Chemical tools for inhibition and activity-based profiling of glucocerebrosidase in vitro and in vivo

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By Shusheng Wang, Leanne Carter, Rodrigo Bravo Verified, Ziyang Zhang, Daniel Tesolin, Benjamin Pluvinage, Manoj Kumar, Zishuo Xu, Ricardo Feldman, Alisdair B. Boraston, Darrell D. Mousseau, Christopher P. Phenix, Omid Tavassoly, Morshed A. Chowdhury, Anshita Madaan, Maa O. Quartey, Jennifer N. Nyarko, Julia Vander Velde, Aarnoud C. van der Spoel
| Cell Chemical Biology Verified
Keywords glucocerebrosidase GBA GBA1 GCase Parkinson’s disease Gaucher disease activity-based probe mechanism-based inhibitor enzyme kinetics ambroxol subtractive enzyme activity assay conduritol B epoxide CBE conduritol aziridine Introduction Glucocerebrosidase (GCase) is a lysosomal β-glucosidase that hydrolyzes glucosylceramides and glucosylsphingosine.
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