Maarja Andaloussi Mäe

Nyckelord: MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Angiopoietin 2; Claudin 5; Single-cell RNA sequencing; Medicinsk vetenskap; Medical Science; Sammanfattning: The blood-brain barrier (BBB) is a specialized vascular interface that protects the central nervous system (CNS) by tightly regulating molecular exchange between the blood and brain parenchyma.

Animals Male heterozygous Ins2AKITA mice11 (referred here as Ins2AKITA) and littermate wild-type controls (referred here as WT) were used for this study. Mice were purchased from Jackson Labs (Bar Harbor, ME) on a C57Bl/6-J background and bred in house at the Scheele Animal House, Karolinska Institute. Animals were housed in Allentown XJ type II long cages (Allentown, NJ), with 12/12 h light-dark cycle and access to water and standard chow ad libitum.

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