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Mabel Seto

As seen in: Nature, JAMA (The Journal of the American Medical Association)
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Articles by Mabel Seto

Blood-based circular RNAs for early diagnosis of Alzheimer’s disease

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By Bridget Phillips, Vaibhav Janve, Menghan Liu, Matt M. Johnson, Katherine Gong, Joseph Lowery Verified, Allison Flynn, William Brock, John Budde, Nikolaos Mellios, Grigorios Papageorgiou, Reisa Sperling, Rachel Buckley, Mabel Seto, John Morris, Joel S. Perlmutter, Paul T. Kotzbauer, Richard Perrin, Timothy J. Hohman, Laura G. Ibáñez, Carlos Cruchaga, Jessie Sanford, Kristy Bergmann, Brenda Sanchez Montejo, Nicholas Sykora
| Nature Verified
Abstract Detection of Alzheimer’s disease (AD) before the development of clinical symptoms is critical for enabling the use of new treatments. Circular RNAs (circRNAs) are highly stable non-coding RNAs enriched in the brain that can cross the blood–brain barrier. Here, analyzing blood data from 1,221 individuals with AD and healthy individuals, we identified 34 circRNAs associated with AD status.
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Parental History of Memory Impairment and β-Amyloid

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By Mabel Seto, Vanderbilt Memory, Timothy J. Hohman, Elizabeth C. Mormino
| JAMA (The Journal of the American Medical Association) Verified
Key Points Question Is parental history of memory impairment associated with brain β-amyloid burden among cognitively unimpaired individuals? Findings In this cross-sectional study of 4413 individuals screened for the Anti-Amyloid Treatment in Asymptomatic Alzheimer (A4) study, individuals with a maternal history of memory impairment had elevated neocortical β-amyloid cross-sectionally compared with individuals with only paternal history or no parental history.
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Telomere length associations with cognition depend on Alzheimer's disease biomarkers

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By Emily Mahoney Verified, Vanderbilt Memory, Logan Dumitrescu, Mabel Seto
| trci.alzdem.com
1. Introduction Telomeres are long, repeated sequences at the end of chromosomes [1x[1]Blackburn, E.H. Structure and function of telomeres. Nature. 1991; 350: 569–573 Google ScholarSee all References1], which typically shorten with each cell cycle due to incomplete replication, leading to cellular senescence or cell death [2x[2]Victorelli, S. and Passos, J.F. Telomeres and cell senescence - size matters not. EBioMedicine. 2017; 21: 14–20 Google ScholarSee all References2].
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