Macayla L. Donegan on Muck Rack

Macayla L. Donegan

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Articles

Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model

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By Fabio Stefanini, Stefano Fusi, Steven A. Siegelbaum, Macayla L. Donegan
| Nature Verified
Abstract The hippocampal CA2 region is essential for social memory. To determine whether CA2 activity encodes social interactions, we recorded extracellularly from CA2 pyramidal neurons (PNs) in male mice during social behavior. Although CA2 neuronal firing showed only weak spatial selectivity, it accurately encoded contextual changes and distinguished between a novel and a familiar mouse.
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