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Articles

Detection of early-stage lung adenocarcinoma using a novel extracellular vesicle and particle-based blood test

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By Daniel P. Salem, Aaron Chevalier, Brittany Grimes, Katherine Yang, MacKenzie King, Mackenzie King, Syrena C. Fernandes, Troy Hawkins, Michael Smith, Michaël Smith, Dawn Mattoon, Ibukunoluwapo O. Zabroski, Timothy Santos-Heiman, Nina A. Insixiengmay, Gabrielle N. Barcaskey, Toumy Guettouche
| Nature Verified
Abstract Tumor-derived extracellular vesicles and particles (EVPs) represent a promising analyte class for early cancer detection. However, discrimination of tumor-derived EVPs from those shed by healthy tissues represents a major analytical challenge. This work describes the design and characterization of a novel proximity ligation-based immunoassay which targets tumor-derived EVPs in plasma displaying four colocalized surface biomarkers.
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