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Macy Stoddard on Muck Rack

Macy Stoddard

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Fatty acid nitroalkene inhibition of LRRK2 hyperactivation and induction of neuroprotection in a model of Parkinson’s disease

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By Ese S. Ekhator, Isabella T Sanders, Sandra Castro, Stacey J. Sukoff Rizzo, Francisco J. Schopfer, Bruce Freeman, Roberto Di Maio, Marco Fazzari, Ahssan Sekandari, Macy Stoddard, Christine Odoux, Timothy Greenamyre
| Nature Verified
Abstract The pathogenic events in Parkinson’s disease (PD), responsible for the loss of dopaminergic neurons and motor function, stem from interacting environmental, genetic, and inflammatory factors. These induce leucine-rich-repeat kinase 2 (LRRK2) hyperactivation, lipid oxidation, protein aggregation and suppression of Nrf2-regulated antioxidant and tissue repair gene expression programs.
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