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Platinum-based neoadjuvant chemotherapy and the predictive role of DNA damage response biomarkers in TNBC: the NeoCarbo study
Abstract Platinum-containing neoadjuvant chemotherapy increases pathological complete response (pCR) rates in triple-negative breast cancer (TNBC), but predictive biomarkers remain incompletely defined. In the multicenter NeoCarbo cohort, we assessed a carboplatin-containing neoadjuvant regimen and examined whether germline homologous recombination deficiency (HRD) and baseline tumor DNA damage response (DDR) activation predict pCR and outcomes.
PANHER study: a 20-year treatment outcome analysis from a multicentre observational study of HER2-positive advanced breast cancer patients from the real-world setting - Laura Pizzuti, Eriseld Krasniqi, Isabella Sperduti, Maddalena Barba, Teresa Gamucci, M
Introduction The overexpression of the human epidermal growth factor receptor-2 (HER2) and inherent gene amplification is reported in 15–20% of breast cancers (BCs).
Burnout of health care providers during the COVID-19 pandemic: Focus on Medical Oncologists
Int J Med Sci 2021; 18(10):2235-2238. doi:10.7150/ijms.54025 Letter Patrizia Vici1, Eriseld Krasniqi1, Laura Pizzuti1, Gennaro Ciliberto2, Marco Mazzotta1, , Daniele Marinelli3, Maddalena Barba1, 1. Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi, 00144 Rome, Italy 2. Scientific Direction, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy 3.
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