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Maddlie Bardol

As seen in: Wiley Online Library
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Articles

Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care

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By Maddlie Bardol, Yucheng Sheng, Manuel A. Baarslag, Adriana Ceci
| Wiley Online Library Verified
1 Introduction There are relatively few pharmacokinetic–pharmacodynamic studies involving sedatives conducted in children, even though these drugs are routinely used in the pediatric intensive care unit (PICU) for pain and sedation management [1]. The CloSed study (CLonidine compared with midazolam for Sedation of children in the intensive care unit) was a trial that aimed to compare clonidine with midazolam for sedation in the PICU [2].
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Pharmacokinetic pharmacodynamic modeling of analgesics and sedatives in children

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By Shan Pan, Joseph F Standing, Maddlie Bardol, Suellen M. Walker
| Wiley Online Library Verified
Modeling approaches Due to age-dependent differences in PK (e.g., clearance, metabolism, distribution) and PD (physiological and behavioral response, susceptibility to side effects), using linear weight-based extrapolation of doses from adults does not usually provide equivalent analgesia or sedation in children of all ages.
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