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Madison Denney on Muck Rack

Madison Denney

As seen in: Nature
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Endothelial cell-intrinsic NOD2 signaling regulates the intestinal immune response through the generation of effector and memory T cells

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By Boyan K. Tsankov, Jennifer Ahn, Charles Carr, Nayanan Nathan, Derek Tsang, Giuliano Bayer, Tapas Mukherjee, Elaine Tam, Jennifer L Gommerman, Stephen E. Girardin, Dana J Philpott, Madison Denney, Lauren Baerg, Alexander Luchak, Bana Samman
| Nature Verified
Abstract Crohn’s disease (CD) involves aberrant intestinal T cell immunity and genetic variants associated with disease development. Notably, mutations impairing NOD2 signaling represent the largest genetic risk factor for CD. Paradoxically, although NOD2 variants are associated with CD, its ligand, bacterial muramyl dipeptide, is a potent stimulator of immunity, long recognized as the minimal component required for the adjuvanticity of complete Freund’s adjuvant.
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