Madusha L. W on Muck Rack

Madusha L. W

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FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation - Nature

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By Noé Seija, Di Noia, Madusha L. W, Gholam Ali
| Nature Verified
Abstract Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination1,2. AID-generated deoxyuracils are recognized and processed by subverted base-excision and mismatch repair pathways that ensure a mutagenic outcome in B cells3,4,5,6. However, why these DNA repair pathways do not accurately repair AID-induced lesions remains unknown.
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