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Mae Woods

As seen in: Cell Reports Medicine, Texas Medical Center

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Articles

Chimeric Antigen Receptor-Induced Antigen Loss Protects CD5.CART Cells From Fratricide Without Compromising On-Target Cytotoxicity

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By Royce Ma, Mae Woods, Phillip Burkhardt, Noah Crooks
| Texas Medical Center
Keywords CD5 Antigens, Humans, Receptors, Chimeric Antigen, Cytotoxicity, Immunologic, T-Lymphocytes, Immunotherapy, Adoptive, Animals, Receptors, Antigen, T-Cell/, chimeric antigen receptor, T cell fratricide, CD5, T cell malignancies, off-tumor toxicity, clinical trials, CAR, fratricide Abstract Chimeric antigen receptor T cells (CART) targeting lymphocyte antigens can induce T cell fratricide and require additional engineering to mitigate self-damage.
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Naive T Cells Inhibit the Outgrowth of Intractable Antigen-Activated Memory T Cells: Implications for T-cell Immunotherapy

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By Sandhya Sharma, Mae Woods, Naren Mehta, Tim Sauer
| Texas Medical Center
BACKGROUND: The wider application of T cells targeting viral tumor-antigens via their native receptors is hampered by the failure to expand potent tumor-specific T cells from patients. Here, we examine reasons for and solutions to this failure, taking as our model the preparation of Epstein-Barr virus (EBV)-specific T cells (EBVSTs) for the treatment of EBV-positive lymphoma.
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Chimeric antigen receptor-induced antigen loss protects CD5.CART cells from fratricide without compromising on-target cytotoxicity

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By Mae Woods, Royce Ma, Phillip Burkhardt
| Cell Reports Medicine Verified
Highlights • CD5 is highly expressed in T cell malignancies and normal T cells • CD5.CAR causes full degradation of CD5 in T cells leading to fratricide resistance • CD5.CAR transiently downmodulates CD5 on target cells in trans • CD5 modulation in trans does not protect target cells from CD5.CART cells long-term Summary Chimeric antigen receptor T cells (CART) targeting lymphocyte antigens can induce T cell fratricide and require additional engineering to mitigate self-damage.
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