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Fetal growth is driven by a bimodal fetal beta cell response and reshaped by a ketogenic diet in a mouse model of maternal diabetes

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By Robert H. Smith Faculty, Magenheim Samuel
| link.springer.com
Maternal diabetes severity dictates fetal growth in a bimodal manner Following doxycycline administration and diabetes induction, we stratified 42 dams aged 13 ± 3.8 weeks at delivery into three groups based on preconception BG levels: non-diabetes (n=11), mild diabetes (n=18) and severe diabetes (n=13) (Fig. 1a). As expected, maternal BG levels were significantly different between the groups both before and during pregnancy (Fig. 1b and ESM Fig. 1a).
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