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Mahalakshmi Harish on Muck Rack

Mahalakshmi Harish

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Articles

The interaction network of the proteasome assembly chaperone PSMD9 regulates proteostasis

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By Joel Christie, C. Merlyn Anthony, Mahalakshmi Harish, Deepti Mudartha
| Wiley Online Library Verified
Functional networks in cells are created by physical, genetic and regulatory interactions. Mapping them and annotating their functions by available methods remains a challenge. We use affinity purification mass spectrometry (AP-MS) coupled with SLiMFinder to discern such a network involving 26S proteasome non-ATPase regulatory subunit 9 (PSMD9), a chaperone of proteasome assembly. Approximately 20% of proteins within the PSMD9 interactome carry a short linear motif (SLiM) of the type 'EXKK'.
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