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Mahamadou Djibo

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Articles

Dual targeting of PI3Kγ and STING overcomes regulatory B cell- and myeloid cell-driven immune suppression in pancreatic cancer

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By Chengyi Li, Fang Ke, Hongyi Zhao, Shuai Mao, Linqi Huang, Miao He, Meilin Wang, Zhongwei Liu, Zhixin Yu, Zhihong Qi, Minal Nenwani, Nicole Peterson, Vaibhav Sahai, Deepak Nagrath, Carrie L. Lucas, Matthias P. Wymann, Wei Gao, Lawrence Fong, Duxin Sun, Mahamadou Djibo, Ana R. Xavier
| Nature Verified
Abstract Both regulatory B (Breg) and myeloid cells in tumors and lymph nodes drive immune suppression in pancreatic cancer. Current strategies to counter immune suppression emphasize myeloid cells but overlook Breg cells. We discovered that STING agonist expanded Breg cells depended on PI3Kγ but not PI3Kδ in pancreatic cancer, whereas activating myeloid cells were independent of PI3Kγ.
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