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Mahel Zeghouf on Muck Rack

Mahel Zeghouf

As seen in: Nature, Frontiers
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Articles

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling - Nature Communications

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By Rodolphe Fischmeister, Sarah Cianférani, Marie Ley, Marie-Hélène Kryszke, Mahel Zeghouf
| Nature Verified
Abstract EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of EPAC1 activation in the cytosol. Here, we discover that anionic membranes are a major component of EPAC1 activation.
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Nox1-based NADPH oxidase regulates the Par protein complex activity to control cell polarization

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By San Martín, Arie Horowitz, Mahel Zeghouf, Anna E. Dikalova
| Frontiers
1 Introduction Cell migration is a fundamental process for embryological development and tissue repair, while aberrant migration participates in diseases such as cancer, atherosclerosis, and restenosis (Schwartz, 1997). Different cells in higher organisms display various migration modes depending on tissue environment, genetic background, and extracellular stimuli.
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