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Articles

Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation-Specific and HIF-Dependent Manner | Cancer Research

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By Mahelet Mamo, I. Chae Ye, Josh W. DiGiacomo, JE Park
| cancerres.aacrjournals.org
Tumor Biology and Immunology Mahelet Mamo, I. Chae Ye, Josh W. DiGiacomo, Je Yeon Park, Bradley Downs and Daniele M. Gilkes DOI: 10.1158/0008-5472.CAN-20-1232 Published November 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below. Abstract Intratumoral hypoxia occurs in 90% of solid tumors and is associated with a poor prognosis for patients.
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Hypoxia alters the response to anti-EGFR therapy by regulating EGFR expression and downstream signaling in a DNA methylation-specific and HIF-dependent manner

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By JE Park, Mahelet Mamo, I. Chae Ye, Josh W. DiGiacomo
| cancerres.aacrjournals.org
Research Article Mahelet Mamo, I. Chae Ye, Josh W. DiGiacomo, Je Yeon Park, Bradley Downs and Daniele M. Gilkes DOI: 10.1158/0008-5472.CAN-20-1232 Abstract Intratumoral hypoxia occurs in 90% of solid tumors and is associated with a poor prognosis for patients. Cancer cells respond to hypoxic microenvironments by activating the transcription factors hypoxia-inducible factor 1 (HIF-1) and HIF-2.
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