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Abstract Reactive neutrophil infiltration can restrain CD8+ T cell expansion in lymph nodes during adoptive T cell therapy (ACT), yet its spatiotemporal regulation remains incompletely understood. Levaraging flow cytometry and multiplex immunofluorescence data, we performed a time-resolved quantitative assessment of immune cell dynamics in tumor-draining lymph node (tdLN) and non-tumor-draining lymph node (non-tdLN) in a melanoma mouse model receiving ACT.
Keywords cancer brain metastasis brain cancer brain metastases tumor immunology immunotherapy intravital imaging lymphocyte recruitment melanoma Introduction Brain metastasis is a frequent complication of melanoma and is associated with a poor prognosis for patients, with a median survival of 4–6 months.1,2 The brain has long been considered an immune-privileged organ.3 However, recently a lymphatic system of the meninges composed of lymphatic vessels located in close proximity along the...
• None Endogenous Glucocorticoid Signaling Regulates Effector Differentiation and Development of Dysfunction in CD8+ T Cells in the Tumor Microenvironment. : • None In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.
Highlights • Comparison of different endogenous target antigens for adoptive T cell therapy • Melanoma immune escape phenotype determined by class and level of target antigen • Targeting melanosomal antigens drives dedifferentiation and myeloid infiltration • Persistence of oncogenic antigen allows for salvage immune checkpoint therapy Summary Tumor immune escape limits durable responses to T cell therapy.
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