Mainz Germany

1 Introduction Autoimmune encephalitis (AE) is an immune-mediated condition that is highly heterogeneous in clinical presentation and provides challenges to diagnosis and monitoring due to a lack of reliable biomarkers. Symptoms can vary, creating a spectrum of syndromes including epileptic seizures, motor and coordination deficits, as well as cognitive and psychiatric deficits such as dementia-like and psychotic episodes affecting children and adults.

2.4.4.1 Using Tajima's D to Categorise AMT Outliers Into Putative Trait Classes To understand the types of selection acting on putative AMT-associated regions, we estimated Tajima's D (TD) in non-overlapping 10 kb windows using ANGSD for each of the 10 populations. To reduce noise, windows with fewer than 500 sites (variant and invariant) were excluded (average number of sites per 10 kb window = 7164). Following Kjærner-Semb et al.

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