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Maithili Shetty on Muck Rack

Maithili Shetty

As seen in: MDPI, BioRxiv
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Articles

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

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By Yahui Yan, Maithili Shetty, Heather Harding, Ginto George
| BioRxiv
Abstract Dephosphorylation of pSer51 of the α subunit of translation initiation factor 2 (eIF2αP) terminates signalling in the integrated stress response (ISR). A trimeric mammalian holophosphatase comprised of a PP1 catalytic subunit, the conserved C-terminally located ~70 amino acid core of a substrate-specific regulatory subunit (PPP1R15A/GADD34 or PPP1R15B/CReP) and G-actin (an essential co-factor) efficiently dephosphorylate eIF2αP in vitro.
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