Majeeda Rasheed

Background Neuroinflammation is the response of the central nervous system to events that interfere with tissue homeostasis and represents a common denominator in virtually all neurological diseases. Activation of microglia, the principal immune effector cells of the brain, contributes to neuronal injury by release of neurotoxic products.

1 INTRODUCTION Plants, particularly sugar cane and rice, contain the straight-chain aliphatic 28-carbon main fatty alcohol octacosanol (OCT), which makes up the majority of policosanol (Irmak & Dunford, 2005). Numerous physiological benefits, such as lower cholesterol and anti-inflammatory effects, have been associated with OCT (Ravelo et al., 2011).

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