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Mak E. Guenther on Muck Rack

Mak E. Guenther

As seen in: BioRxiv
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Articles

Intradental mechano-nociceptors serve as sentinels that prevent tooth damage

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By Elizabeth Ronan, Akash Gandhi, Brian S.C. Constantinescu, Mak E. Guenther
| BioRxiv
Abstract Pain is the anticipated output of the trigeminal sensory neurons that innervate the tooth's vital interior; however, the contribution of intradental neurons to healthy tooth sensation has yet to be defined. Here, we employ in vivo Ca2+ imaging to identify and define a population of myelinated high-threshold mechanoreceptors (intradental HTMRs) that detect superficial structural damage of the tooth and initiate jaw opening to protect teeth from damage.
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