MALABENDU JANA

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CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description jnc16084-sup-0001-Supinfo.zipZip archive, 664.2 KB Data S1. REFERENCES , , , , , , & (1998). Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: Models for multiple sclerosis with primary oligodendrogliopathy. The American Journal of Pathology, 153, 801–813.

Abstract : Parkinson’s disease (PD) is the second most common neurodegenerative disorder in human and loss-of-functions DJ-1 mutations are associated with a familial form of early onset PD. Functionally, DJ-1 (PARK7), a neuroprotective protein, is known to support mitochondria and protect cells from oxidative stress. Mechanisms and agents by which the level of DJ-1 could be increased in the CNS are poorly described.