Malcolm LeBarron McLeod

News|Articles|October 19, 2026 Author(s)Richard Bade , Malcolm McLeod , John Chasse Richard Bade and Malcolm McLeod explain to LCGC International how chromatography detects drug trends in wastewater. Drug and alcohol use is a major problem in Australia, both in terms of cost to society and impact on health. A recent national survey found that nearly half of Australians aged 14 and up have tried an illegal drug at some point in their lives.

News|Articles|October 19, 2026 (Updated: October 19, 2026) Author(s)Richard Bade , Malcolm McLeod , John Chasse Richard Bade and Malcolm McLeod explain to LCGC International how liquid chromatography-tandem mass spectrometry (LC-MS/MS) detects drug trends in wastewater. Drug and alcohol use is a major problem in Australia, both in terms of cost to society and impact on health.

Abstract The epithelial neutral amino acid transporter B0AT1 (SLC6A19) is the major transporter for the absorption of neutral amino acids in the intestine and their reabsorption in the kidney. Mouse models have demonstrated that lack of B0AT1 can normalize elevated plasma amino acids in rare disorders of amino acid metabolism such as phenylketonuria and urea-cycle disorders, implying a pharmacological approach for their treatment.