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Articles by Malcolm Risk
Online causal inference with application to near real‐time post‐market vaccine safety surveillance
CONFLICT OF INTEREST STATEMENT The authors declare no potential conflict of interests. Supporting Information Filename Description sim10095-sup-0001-Supinfo.zipZip archive, 140.4 MB Data S1: Supporting Information. REFERENCES 1, , , , , . Methods for observational post-licensure medical product safety surveillance. Stat Methods Med Res. 2015; 24(2): 177-193. 2, , , et al.
Risk of Blood Clots After COVID-19 Vaccination and Infection: A Risk-Benefit Analysis
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 25 April 2024 / Approved: 25 April 2024 / Online: 26 April 2024 (09:30:41 CEST) Tran, H.N.; Risk, M.; Nair, G.B.; Zhao, L. Risk of Blood Clots After COVID-19 Vaccination and Infection: A Risk-Benefit Analysis. Preprints 2024, 2024041703. https://doi.org/10.20944/preprints202404.1703.v1 Tran, H.N.; Risk, M.; Nair, G.B.; Zhao, L. Risk of Blood Clots After COVID-19 Vaccination and Infection: A Risk-Benefit Analysis.
Leading digit bias in hemoglobin thresholds for red cell transfusion
CI confidence interval Hb hemoglobin IQR interquartile range PMH Princess Margaret Cancer Center RBC red blood cells SD standard deviation TGH Toronto General Hospital TWH Toronto Western Hospital UHN University Health Network 1 INTRODUCTION Red cells are the most frequently transfused blood component, given to about one in seven hospitalized patients.1-3 About a quarter of red cell transfusions are inappropriate when evaluated by guideline criteria.4, 5 Every transfusion originates from an...
RISK OF THROMBOEMBOLISM AFTER COVID-19 VACCINATION AND COVID-19 INFECTION.
The authors have declared no competing interest. This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI158543]. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: - Institutional Review Board (IRB) of Corewell Health.
Vaccine Effectiveness, School Reopening, and Risk of Omicron Infection Among Adolescents Aged 12-17 Years
The BNT162b2 (Pfizer-BioNTech) is approved for adolescents aged 12–17 years. We estimated BNT162b2 vaccine effectiveness (VE) and a booster dose effectiveness in adolescents aged 12–17 years and the impact of opening schools and the Omicron variant on risk of SARS-CoV-2 infection in adolescents. We used logistic regression with a test-negative design controlling for gender and race to estimate BNT162b2 VE and the effectiveness of a booster dose in adolescents aged 12–17 years.
COVID-19 vaccine effectiveness against omicron (B.1.1.529) variant infection and hospitalisation in patients taking immunosuppressive medications: a retrospective cohort study
Summary Background There is a scarcity of research regarding the effectiveness of the mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) COVID-19 vaccines in patients taking immunosuppressant medications, and no data are published to date pertaining to their effectiveness against omicron (B.1.1.529) variant SARS-CoV-2 infection and hospitalisation.
Efficacy of COVID-19 vaccines in patients taking immunosuppressants
Discussion We found that immunosuppressed individuals who had received one of the three approved COVID-19 vaccines were at substantially lower risk of SARS-CoV-2 infection compared with those who were unvaccinated. Specifically, we found that BNT162b2 and mRNA-1273 vaccines were highly effective at preventing SARS-CoV-2 infection in immunosuppressed individuals.
Efficacy of COVID-19 vaccines in patients taking immunosuppressants
Efficacy of COVID-19 vaccines in patients taking immunosuppressants Free http://orcid.org/0000-0003-2193-1245Chen Shen1, Malcolm Risk1, Elena Schiopu2, Salim S Hayek3, Tiankai Xie1, Lynn Holevinski4, Cem Akin5, Gary Freed6, Lili Zhao1 1Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA 2Department of Rheumatology, University of Michigan Michigan Medicine, Ann Arbor, Michigan, USA 3Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA 4Data Office...
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