Malenka Zimmermann on Muck Rack

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High Tau Expression Correlates with Reduced Invasion and Prolonged Survival in Ewing Sarcoma

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By Florencia Cidre-Aranaz, Claudia Magrin, Jing Li, Malenka Zimmermann
| biorxiv.org
Abstract The microtubule-associated protein Tau (encoded by the MAPT gene) is linked to a family of neurodegenerative disorders defined as tauopathies, which are characterized by its brain accumulation in neurofibrillary tangles and neuropil threads. Newly described Tau functions comprise DNA protection, chromatin remodeling, p53 regulation and cell fate modulation, suggesting a role of Tau in oncogenesis.
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