Malin Hagberg Thulin

Abstract Better tools to predict the likelihood of a recurrence of prostate cancer (PC) after a radical prostatectomy are needed and would provide more personalized therapies for the patients early enough to efficiently control the disease burden. In this study, the transcriptome profiles from matched malignant and adjacent benign prostate tissue were compared in 41 patients to facilitate the identification of novel markers for PC aggressiveness.

Abstract Men develop larger infarct sizes than women after a myocardial infarction (MI), but the mechanism underlying this sex difference is unknown. Here, we demonstrated that blood neutrophil counts post-MI were higher in male than female mice. Castration-induced testosterone deficiency reduced blood neutrophil counts to the level in females and increased survival post-MI. These effects were mimicked by Osterix-directed ablation of the androgen receptor in bone marrow (BM).

Abstract Sex steroids, such as androgens and oestrogens, are hormones that primarily regulate the physiology of reproductive organs and maintain reproductive capacity in both men and women, respectively. Later in life, these sex steroids can become major promoters of the growth of cancer in the reproductive tissues, such as the breast and prostate, with breast cancer being the most common cancer in women and prostate cancer being the second most common cancer in men.