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Malte Christoph Rühlemann on Muck Rack

Malte Christoph Rühlemann

As seen in: Nature, Gut Journal, BioRxiv
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Articles

On the limits of 16S rRNA gene-based metagenome prediction and functional profiling

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By Monica Steffi Matchado, Malte Christoph Rühlemann, Tim Kacprowski, Sandra Reimeiter
| BioRxiv
Abstract Molecular profiling techniques such as metagenomics, metatranscriptomics or metabolomics offer important insights into the functional diversity of the microbiome. In contrast, 16S rRNA gene sequencing, a widespread and cost-effective technique to measure microbial diversity, only allows for indirect estimation of microbial function. To mitigate this, tools such as PICRUSt2, Tax4Fun2, PanFP and MetGEM infer functional profiles from 16S rRNA gene sequencing data using different algorithms.
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Functional host-specific adaptation of the intestinal microbiome in hominids

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By Malte Christoph Rühlemann, Corinna Bang, Jan F Gogarten, Britt Hermes
| BioRxiv
Abstract Fine-scale knowledge of the changes in composition and function of the human gut microbiome compared that of our closest relatives is critical for understanding the evolutionary processes underlying its developmental trajectory.
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Comparative metagenomics reveals host-specific functional adaptation of intestinal microbiota across hominids

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By Malte Christoph Rühlemann, Corinna Bang, Britt Hermes, Jan F Gogarten
| BioRxiv
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