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Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups

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By Alina M. Hartmann, Lorenz Bastian, Johannes Maria Haas, Malwine J Barz
| biorxiv.org
Abstract KMT2A-rearranged B-cell acute lymphoblastic leukemia (KMT2Ar B-ALL) exhibits significant heterogeneity in age of onset, developmental origins, and clinical outcomes. The interplay of individual factors influencing early treatment response within this high-risk molecular subtype remains poorly elucidated.
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